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People with previous GI conditions Individuals with a history of gastroparesis, irritable bowel syndrome, inflammatory bowel disease, or chronic nausea are among the strongest candidates for microdosing

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One major mechanism is the loss of ER expression , rendering the tumor unresponsive to estrogen-blocking therapies

[1] [2] Additionally, when used with insulin or sulfonylureas, hypoglycemia may occur, potentially causing adrenergic symptoms including palpitations or chest discomfort

It is also approved for chronic weight management in adults who are obese (BMI 30) or overweight (BMI 27) and have at least one weight-related comorbid condition, such as hypertension or dyslipidemia

Managing side effects during dose titration Every dose increase brings the possibility of temporary side effects