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However, it is critical to distinguish between biological activity and therapeutic efficacy: these biomarker changes did not translate into any measurable clinical benefit, and should therefore be interpreted as evidence of limited central engagement rather than as support for the prevention-dominant hypothesis

25 Galectin Therapeutics next NAVIGATE study will consist of an 18-month Phase 2b extension study followed by an interim analysis to consider any adaptive treatment modifications before a final evaluation in an 18-month Phase 3 trial

Author contributions Andr J

2025;48(1 Suppl 1):S23951

Although these trials are valuable, they were excluded within the scope of this review because they lacked head-to-head comparison with prandial insulin
However, they need to ensure that the food has enough nutrients when it moves slowly from the stomach to the intestine, where absorption occurs
