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GI Amplification Is the Primary Concern The most clinically significant and best-supported concern is amplified gastrointestinal discomfort

This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits

ESC Heart Fail 8(3):22102219

Ozempic is generally well-tolerated, with the most common side effects being gastrointestinal, including nausea, diarrhoea, and vomiting

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Tirzepatide (Mounjaro, Zepbound) As a dual GIP and GLP-1 agonist, tirzepatide provides a closer comparison to Retatrutides mechanism