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BaumeierCSchluterLSaussenthalerSLaegerTRodigerMAlazeSAet al

Interestingly, GLP-1RAs have been reported to activate the metabolism of brown fat and increase the energy expenditure in rodents through exercise activities independent of the sympathetic nervous system pathway (3)

Lean Muscle Mass: Important for metabolism, insulin sensitivity, and strength

340 Interestingly, DIRKO mice also exhibit increased energy expenditure which demonstrates that incretin hormone action may negatively regulate nutrient catabolism

Last reviewed: April 28, 2026

Together, these inputs help preserve lean mass during periods of weight change