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Off-Target Binding: Transporters, Serotonin Receptors, and Clinical Consequences SSRIs are relatively selective for SERT but show low-affinity interactions with other monoamine transporters (norepinephrine transporter (NET) and dopamine transporter (DAT)) and multiple serotonin receptor subtypes

Patients should be counselled before starting treatment that gastrointestinal symptoms are common, particularly in the early weeks, and that they often diminish over time as the body adjusts to the medication

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Gene 568 , 114115 (2015)