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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on substance use disorder (SUD)-related behavioural effects of drugs and alcohol: a systematic review

Long trials and reviews have not confirmed that link, and the early fears have largely been dispelled (Jalleh 2026)

& Okovityi, S

Eli Lilly says full data from its latest Phase 3 trial will be published in a peer-reviewed journal at a future date.

Differences between groups were compared via two-tailed unpaired t tests for two groups, one-way analysis of variance (ANOVA) followed by Dunnetts multiple comparison test for multiple groups, or two-way repeated-measures ANOVA followed by the Bonferroni multiple comparison test for multiple groups and time courses

In fact, there are reports which demonstrate that administration of both a probiotic microorganism strain and prebiotics influences GLP-1 release and signaling