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Extended-release exenatide (Bydureon BCise) has an apparent terminal half-life of approximately 2 weeks due to its depot formulation, with drug concentrations potentially persisting for 8-10 weeks after discontinuation

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The fat loss mechanism is indirect: elevated GH shifts the body toward fat oxidation and lean mass preservation

Jastreboff et al., 2023 (NEJM): estudio fase 2 en adultos con obesidad sin diabetes, reduccin ponderal media de 24.2% a la semana 48 con 12 mg semanales, el mayor efecto reportado para un frmaco incretnico hasta la fecha de publicacin

The same finding had been reported by a prior larger meta-analysis (6,914 patients with overweight or obesity and T2DM) over 8 studies 184,185,189,190,191,192,193,194 , but only when the largest study that also included non-diabetic participants 193 was excluded in a sensitivity analysis 195

J Clin Endocrinol Metab 95:879886 Nauck MA, Siemsgl J, rskov C, Holst JJ (1996) Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections