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The GLP-1 RA and Central Nervous System (CNS) Inflammation It is well known that CNS inflammation plays a major role in the pathophysiology of NDs.82 In type 2 diabetes-associated cognitive impairment animal models and high-glucose in vitro studies, neuroinflammatory markers, such as IL-1 , TNF-, IL-6, and MCP-1, and inflammatory responses, such as toll-like receptor 4, cyclooxygenase 1 (COX1), COX2, NF-B, leukocyte common antigen, and inducible nitric oxide synthase were increased in the brain.8388 Among participants with dementia and AD pathology, type 2 diabetes had a significantly positive relationship with JNK.89 In vitro, high glucose increased the expression of inflammasome recombinant NLR Family, pyrin domain containing protein 3 (NLRP3) markers in hippocampal cells.90 Besides, CNS inflammation is an immune response mediated by microglia and astrocytes