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Moreover, peptides in GLP-1 drugs are derived from living cells through recombinant DNA technology, which makes their manufacturing process more complex and expensive than traditional pills

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Egan J.M., Montrose-Rafizadeh C., Wang Y., Bernier M., Roth J

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Data presented herein support the notion that prolonged exposure to GLP-1R stimulation can also induce glucose competence by a secondary mechanism involving up-regulation of glycolytic enzymes, and consequently glycolytic flux, arguably the most important stimulus-secretion coupling factor generating pathway in -cells