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Side effect management

This can lead to increased feelings of satiety

(R-KS) sent a bipartisan letter to the FDA flagging Hims & Hers' ad and accusing the company of misleading patients "by omitting any safety or side effect information when promoting a specific type of weight loss medication." Under federal law and regulations, FDA requires that prescription drug advertisements be truthful, not misleading, and balancedfailure to do so risks FDA enforcement action, including civil monetary penalties, Durbin and Marshall said in the letter

Combining GLP-1 with estrogen into a stable conjugate that stimulates all GLP-1R-expressing cells but only those estrogen receptor-expressing cells that contain GLP-1R leads to better glycemic control and synergistic weight loss, as well as a reduction in food reward, the latter 2 mediated by the CNS (42, 43)

Conversely, depression can undermine self-care behaviors that are necessary for effective diabetes management, such as regular medication adherence, appropriate dietary choices, and consistent physical activity [30, 33]

And for some of those people, weight loss medications like Wegovy (semaglutide) might be the answer