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Description
Serious but rare risks include hypoglycemia (low blood sugar), acute pancreatitis (severe, persistent abdominal pain often with vomiting), acute gallbladder disease (sudden right-upper abdominal pain that may radiate to the shoulder), non-arteritic anterior ischemic optic neuropathy (sudden, potentially permanent vision loss), mood changes, and severe allergic reactions with breathing difficulty or swelling of the lips, tongue, or throat

Glucagon-mediated enhancement in insulin secretion, independent of GcgR-mediated glucose production, has been suggested to occur via paracrine activation of the -cell GLP-1 receptor in the post-prandial state [174], [2], [25]

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Postprandial production of GLP-1 increases insulin secretion from pancreatic beta cells and suppresses glucagon secretion from pancreatic alpha cells

The median treatment duration for participants was 15.9 months
