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[37] More than a dozen peptides and other substances have been isolated from the Gila monster's venom, including hyaluronidase, serotonin, phospholipase A 2 , and several kallikrein-like glycoproteins responsible for the pain and edema caused by a bite, without producing a compartment syndrome

DISCUSSION Using structure-guided computational protein design, we developed a de novo IR agonist, RF-409, that activates IR through a noncanonical binding geometry

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