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Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

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Common adverse events included nausea (60% in the 12 mg group), diarrhea (37%), and constipation (27%), consistent with the GLP-1 agonist class effect on gastrointestinal motility

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