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There are several important interactions to consider when taking semaglutide and levothyroxine together: Pharmacokinetic Interaction with Oral Semaglutide : According to FDA labeling, oral semaglutide (Rybelsus) increases levothyroxine exposure by approximately 33% when coadministered

This convenience factor is a massive reason why these newer-generation medications have become the standard of care

doi: 10.1111/j.1476-5381.2009.00486.x [DOI] [PMC free article] [PubMed] [Google Scholar] 60

The alanine at position 8, the residue immediately adjacent to the DPP-4 cleavage bond, is replaced by alpha-aminoisobutyric acid (Aib), a non-canonical, doubly methylated amino acid whose steric bulk blocks protease access [1]

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