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Hallucinations are more likely to be experienced by people with existing neurological disorders, such as attention deficit hyperactivity disorder (ADHD), mental illness, or use of other mind-altering drugs

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Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure

Other barriers include nausea, constipation, or appetite suppression so strong that patients struggle to eat enough protein

doi:10.1523/JNEUROSCI.0529-11.2011 71

However, their capacity to cross the BBB varies substantially across compounds and is influenced by a combination of molecular weight, hydrophilicity, protein binding, susceptibility to enzymatic degradation, and structural modifications [66]