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placebo in adults with overweight or obesity without diabetes (STEP 3), mean body weight decreased 16.0% with semaglutide compared with 5.7% with placebo, both as adjunct to intensive behavioral therapy (ETD 10.3%

Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, which reflect hepatocellular injury, typically decrease during GLP-1 therapy

In rare cases, serious regurgitant cardiac valvular disease has occurred

Stokes T et al

This concern is real but often overstated, particularly in people who are insulin sensitive or adapting to fat burning, and it becomes secondary to the muscle preservation imperative when semaglutide is involved

Exp Mol Med 54(4):377392 Clemmensen C, Mller TD, Woods SC, Berthoud H-R, Seeley RJ, Tschp MH (2017) Gut-brain cross-talk in metabolic control