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Blockage of this pathway can curb the activation of HSCs and prevent liver fibrosis (W et al., 2022)

About 75% of users see GI symptoms clear within 4 weeks at a stable dose, per the Zepbound FDA prescribing information

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If there is no improvement after a couple of weeks, consult a clinician to check for other causes or to adjust the plan.

Who benefits most: Extremely needle-sensitive patients Very young children Patients with anxiety disorders Those with previous trauma related to injections Realistic expectations: Noticeably slower injection time Requires patient technique More expensive May not be covered by all insurance plans Availability: Less common

This figure represents an immediate hit to Novos top line once the new pricing takes effect in 2027, and the IRAs effect on profitability is likely to be even more significant