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doi: 10.1016/j.clinthera.2007.01.013 32 U

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Healthcare professionals and patients are encouraged to report suspected adverse reactions via the Yellow Card Scheme (yellowcard.mhra.gov.uk), and the overall benefit-risk profile remains favourable for appropriate patients

According to FDA prescribing information, this heart rate elevation typically averages approximately 1-4 beats per minute above baseline, though a subset of patients may experience more pronounced increases of 10 beats per minute or more