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Results announced in September 2025 and published in The Lancet in February 2026 demonstrated orforglipron's superiority over oral semaglutide on both HbA1c reduction (approximately 2.2 vs 1.4 percentage points) and weight loss (approximately 9.2% vs 5.3%)

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By month 34, most patients tolerate semaglutide well, with only occasional flares related to specific meals or stress

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Exploring the broader actions GLP-1-receptor agonists may influence provides an opportunity to understand how they may improve not just respiratory health but also the many other medical challenges our patients face, including cardiovascular diseases, chronic kidney disease, sleep apnea and even depression, said Cahill, Associate Professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine

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