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"The future of treatment for obesity is multidisciplinary, comprehensive approach where it's medicine, it's nutrition, it's exercise, it's mental health, and also surgery in there," Chandler said.

Efficacy endpoints were change from baseline in HbA 1c and body weight (and, for the separate PIONEER 8 subgroup analysis, change from baseline in insulin dose) at the planned end of treatment (weeks 26, 52 or 78, according to the trial)

These drugs activate specific receptors in the pancreas and brain, supporting both blood sugar control and appetite suppression

Reaching that target matters enormously because it significantly reduces the risk of diabetes-related complications including neuropathy, retinopathy, and kidney disease

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Most are mild to moderate, but lead some people to discontinue treatment