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Gastrointestinal side effects were most prevalent during the dose-escalation period the weeks during which the dose is gradually increased towards the target maintenance level

This suggests inhibition of vagal cholinergic input into the stomach with a concomitant increase in gastric volume, though the exact mechanism is not clear

doi:10.1016/s0140-6736(19)31149-3 Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjth TV, et al

Semaglutide and risk of suicidal ideations