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In addition, their impact on gastric motility has raised perioperative concerns, particularly related to delayed gastric emptying, which increases the risk of vomiting and aspiration during induction of general anesthesia

Further studies should now focus on non-inferiority studies comparing these new oral molecules against currently recommended injectable GLP-1 RAs to have a clear comparison between these families of medications

doi: 10.1016/S0021-9258(19)36565-2 87 YoungAAGedulinBRBhavsarSBodkinNJodkaCHansenBet al

Guirguis says combination treatments such as this could offer additive or synergistic effects meaning that patients have a better chance of responding to at least one of the mechanisms and could experience fewer GI side effects as a result of the dual approach