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None of this replaces a conversation with your prescriber but it should help you have a more useful one

32 The Gln 19 adopted in tirzepatide seems to be crucial to GIP activity, but may still affect GLP-1 activity

Patients with pre-existing cardiovascular risk factors should be monitored appropriately when initiating tirzepatide therapy, particularly during dose escalation when gastrointestinal effects are most pronounced

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Retatrutide has not received FDA approval and remains investigational

Additionally, the Semaglutide brand Wegovy has been approved to reduce the risk of major cardiovascular events, such as heart attack and stroke, in diabetic patients