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These receptors are functional as mice receiving exendin-4 i.v
These data highlight the importance of closely monitoring the safety profile of GLP-1RA plus SGLT2i combination therapy in routine clinical practice

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On the other side, sustained GLP1R/cAMP signaling could dampen or alter the normal Ca 2+ oscillation pattern via Ca 2+ -cAMP cross-talk [72]

Glucagon receptor activation increases energy expenditure directly by stimulating thermogenesis in adipose tissue and hepatic fat oxidation

EClinicalMedicine, 57, 101865
