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Recent research has sought to address this gap by developing a new generation of incretin-based medications that simultaneously target multiple metabolic pathways, aiming to improve both metabolic control and downstream organ health

Moreover, cocaine-related behaviors are enhanced in GLP-1R knockout mice (Harasta et al., 2015), providing further evidence for the GLP-1Rcocaine interaction

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Appendix 2 in Supplementary File summarizes some of the most well-known natural substrates of DPP-4 and their corresponding biological functions

Most realize that steady, incremental tweaks to daily habits, rather than a hot pursuit of quick fixes, maintain results long-term

However, they emphasized that no direct clinical cause-and-effect relationship has been proven