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Unlike SGLT2 inhibitors (another class of diabetes medication such as dapagliflozin or empagliflozin), which work by causing the kidneys to excrete excess glucose in urine and consequently increase urination, GLP-1 receptor agonists do not affect renal glucose handling or increase urinary glucose excretion

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When the benefit outweighs the side effect, and when it might not For most patients, the metabolic benefits of GLP-1 therapy, including improved cardiovascular risk factors, better insulin sensitivity, reduced visceral fat, and meaningful weight loss, far outweigh a temporary or modest change in libido