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Notably, reported observations in research contexts include changes in glucose handling, delayed gastric emptying during early postprandial phases, and modulation of appetite-related biomarkers

Whether these improvements are sustained and confirmed at Phase 3 scale remains to be established

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Beyond routine glucose and lipid panels, endocrine studies increasingly include microbiome profiling, bile-acid pools, and hepatokine/adipokine panels (FGF21, adiponectin) to explain shifts in substrate preference

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Functional studies demonstrate that this modification maintains equipotent activity compared to unmodified peptides while providing superior metabolic stability