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Under-consumption of food, and even water, is a major concern, and GLP-1 RA users often experience substantial loss of lean body mass, sagging skin due to rapid weight loss, nutrient deficiencies, and chronic dehydration

Building on this, the partners have agreed to co-develop laboratory developed tests (LDTs) to enable enrichment of clinical trials with strong responders in new indication areas with high unmet need

Spiller RC, Trotman IF, Higgins BE, Ghatei MA, Grimble GK, Lee YC, et al

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Plaintiffs argue that manufacturers failed to issue adequate warnings to patients and healthcare professionals regarding these risks