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It might not always mean increasing the dose

24 To explore the possibility of residual confounding (eg, by underlying health status or health careseeking behavior), we used a negative outcome control by evaluating differences in risk of fractures during the follow-up period (eTable 6 in Supplement 1)
VadiniFSimeonePGBoccatondaAGuagnanoMTLianiRTripaldiRet al

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Chronic dry mouth increases the risk of tooth decay, cavities and gum disease
"Consumption of Preserved Egg Is Associated with Modestly Increased Risk of Nonalcoholic Fatty Liver Disease in Chinese Adults"
