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Generally, surrogate endpoints are expected to predict clinical benefits
Key viscerosensory peptides released from the gut are the incretin hormones GLP-1 and gastric inhibitory peptide (GIP), CCK, and PYY [74, 84, 108], [109], [110]
For example, the reduction in CVD associated with increased use of GLP-1 RAs may come at a relatively high cost, but this cost represents a shift from the human domain (i.e
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