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Kardie Tobb, DO, MS, FASPC, FACC, a boardcertified preventive cardiologist and the medical director for the Cone Health HeartCare Womens Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results youre hoping for, including: You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor High intake of liquid calories , including alcohol and ultra-processed foods Not getting enough protein , which can leave you persistently hungry and makes it harder to feel full Advanced diabetes or insulin resistance Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain Not adhering to your dosing schedule , such as inconsistent weekly injections or missed doses Differences in gut hormones or genetics And just because your GLP-1 isnt working immediately doesnt mean it wont work for you

Theyre an amazing source of vitamins, minerals, fiber

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Well cover: New human data How we have been misinterpreting existing evidence How GLP-1s might even support muscle mitochondria And how to preserve muscle while losing fat If youre committed to grappling with the nuance of health and metabolism, Id love to have you join the StayCurious Metabolism premium community: the fastest-growing premium newsletter on the platform and a Top 3 Global Bestseller in Science

Avoiding processed foods and sugary beverages is also crucial

Moreover, drug-induced lupus (DIL), with clinical manifestations similar to SLE, is an autoimmune phenomenon caused by exposure to certain drugs [287]