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The tissue becomes less vascularized, meaning less blood flow reaches the area to carry the medication into systemic circulation

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Monitoring heart health during treatment is recommended, especially for individuals with pre-existing cardiovascular conditions

Track weight, waist, appetite, side effects, and medication questions so the clinician can make safe dose decisions

NAUSEA Eat smaller, more frequent meals Avoid fatty, greasy, or fried foods Choose bland foods when nauseous Ginger tea or ginger chews Avoid lying down after eating CONSTIPATION Increase fiber intake gradually Stay hydrated (8+ glasses daily) Consider a fiber supplement Light physical activity DIARRHEA Avoid high-fat foods Limit artificial sweeteners Stay hydrated to replace fluids Consider probiotics INJECTION TIPS Inject on the same day each week Try evening injections to reduce daytime nausea Can be injected with or without food While rare, some side effects require immediate medical attention: Pancreatitis Warning Signs Severe abdominal pain that won't stop Pain radiating to your back Persistent nausea and vomiting Gallbladder Problems Pain in upper right abdomen Fever Yellowing of skin or eyes Allergic Reactions Difficulty breathing Severe rash or itching Swelling of face, lips, or throat Hypoglycemia Risk Most common with insulin or sulfonylureas Shakiness, sweating, confusion Keep fast-acting glucose available How Tirzepatide Side Effects Compare to Other GLP-1 Medications All three GLP-1 medications, including semaglutide (Ozempic/Wegovy), tirzepatide, and retatrutide (investigational triple agonist), share similar GI side effects, but rates and mechanisms differ