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However, this hypothesis requires validation through rigorously designed clinical trials before broader clinical adoption can be considered

The presence of GLP-1 receptor agonists in these products increased the risk of gastrointestinal complications, ileus, bowel obstruction, and NAION, but the manufacturers knew that such information would discourage consumers from buying and withholding this information

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Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs