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- Drugs.com Tirzepatide versus Semaglutide Once Weekly in Patients with Type ...

revealed that high glucose increased DNA methylation in the promoter regions of CREB and BDNF, two genes critical for neuronal growth and synaptic plasticity

For weekly formulations like tirzepatide, discontinuation was typically advised at least one week before surgery, accounting for the medication's half-life of approximately 5 days

Lancet 2021;398:181124

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2)

This makes it a good choice for people with diabetes
