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At week 72, semaglutide was more effective than placebo at resolving steatohepatitis (a type of fatty liver disease) without worsening liver fibrosis (62.9% vs

FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases

The key to successful use of these drugs, says Dr Williams, is ongoing support, motivation and expertise to ensure that people do all of the right lifestyle and psychological interventions alongside the medication. The large landmark studies which initially proved the effectiveness of these drugs for weight loss all incorporated lifestyle advice and support, not just a leaflet as many online prescribers give.' Example exercise programme 'For people using GLP-1 medications, the goal is muscle preservation, metabolic protection and sustainability, not extreme calorie burn,' says Dr Ajaz

GLP-1 nutrition counseling involves structured assessments, ongoing monitoring, and collaborative care that makes a measurable difference in patient outcomes

Consistency matters less than with daily medications

Rare but serious effects include pancreatitis, gallbladder problems, kidney injury, and thyroid tumors