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GLP-1 secreting L-cells are mainly localized in the distal gut (ileum-colon) [11-12]

As the scientific community continues investigating this innovative compound, new discoveries will undoubtedly emerge, furthering our understanding of metabolic regulation and cellular signaling

10.1016/j.preteyeres.2024.101261 [DOI] [PubMed] [Google Scholar] Bu L

The most recent understanding of this deficit suggests that it relates to deterioration of the GLP-1 effect, with impaired capacity to secrete insulin, increasing insulin resistance, and hyperglycemia, perhaps leading to a decrease in GLP-1 receptor expression and resulting in GLP-1 resistance (7)

This was also true for the risk for first-time biologic prescriptions at 5 years

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