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26 Hemorrhage, edema, ischemia, and necrosis can ensue

7.6 Reframing complexity as translational opportunity Collectively, the neuroendocrine and immunemetabolic peptide systems reviewed in this section challenge the assumption that therapeutic targets must be narrowly defined, peripherally restricted, and mechanistically simple

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27 Primarily, GLP1 (736) lowers blood glucose levels by promoting insulin secretion and decreasing glucagon release in a glucosedependent manner by the mTORdependent HIF1 activation pathway in pancreatic cells (Figure 1)

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