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GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) act on the brain as well as the gut, and a 2026 real-world cohort study from Kamel-Abusalha et al

In most cases, this effect is temporary and improves as the body adapts to changes in appetite, digestion and metabolism

Will I be prescribed a GLP-1 to lose weight

The probiotic strain Zenwise adds, Bacillus subtilis, probably helped to ease some of those stomach woes and keep my microbiome healthy

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Seek immediate medical attention (A&E or call 999) if you develop: Severe, persistent abdominal pain radiating to the back (potential pancreatitis) Bloody or black, tarry stools Persistent vomiting with inability to keep down fluids Signs of severe dehydration or altered consciousness Symptoms of bowel obstruction (severe bloating, inability to pass gas or stool, severe cramping) For urgent but non-life-threatening concerns outside of GP hours, contact NHS 111 for advice