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Meanwhile, orforglipron demonstrated significant weight loss efficacy [8] consistent with injectable GLP-1 medicines

Conclusion GLP-1RAs show significant promise as a potential disease-modifying therapy for neurodegenerative and inflammatory eye diseases, acting through both systemic metabolic improvements and direct ocular mechanisms, representing a paradigm shift beyond their metabolic indications.

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GLP-1s are a class of medications originally approved for type 2 diabetes management that have seen dramatic growth in prescribing following expanded approvals for chronic weight management

Millions of Americans have turned to cheaper, compounded versions of Ozempic and Wegovy

Furthermore, post hoc subgroup analyses of cardiovascular outcome trials have suggested a greater cardiorenal protection in patients treated with a combination versus either monotherapy