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Retatrutide is a synthetically engineered 39-amino-acid peptide developed to activate three separate G protein-coupled receptors (GPCRs): Glucose-Dependent Insulinotropic Polypeptide (GIP) receptor Glucagon-Like Peptide-1 (GLP-1) receptor Glucagon (GCGR) receptor Because it interacts with all three pathways simultaneously, researchers commonly describe Retatrutide as a triple receptor agonist rather than a single or dual-pathway peptide

Cardiovascular outcomes with tirzepatide versus dulaglutide in type 2 diabetes

doi: 10.1016/j.smrv.2016.12.003

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