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Apart from the digestive system, GLP-1 is produced in the brain, especially in the nucleus tractus solitarius (NTS), where it functions as a neurotransmitter

Bak, et al (2014)

Sarmela Sunder, MD, a Beverly Hills-based double board-certified facial plastic surgeon, explains to Plastic Surgery Practice how GLP-1 medications like Ozempic can lead to skin laxity and collagen loss

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Ensure adequate sleep (79 hours nightly), as sleep deprivation independently increases headache susceptibility

The gradual titration is designed to allow the body to adjust to GLP-1 receptor activation and minimize gastrointestinal side effects during the initial treatment period