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Its purpose was to determine whether the drug, which belongs to a class called GLP-1 receptor agonists, could reduce the symptoms of PAD in people with mild to moderate symptoms early in the course of their disease

Nevertheless, semaglutide has been reported to cause thyroid C-cell carcinoma in rat studies and the peptide is accordingly contraindicated in subjects with a history of thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2) [34]

doi: 10.1530/JOE-16-0450 8 LeeSTsirbasAGoldbergRAMcCannJD

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