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The most commonly reported side effects of retatrutide in Phase 2 clinical trials are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation

These injuries can be permanent, debilitating, and life-altering
doi:10.1038/nature11319
Early studies show strong potential for safer glucose control, fat reduction, and muscle preservationaddressing a major concern associated with current GLP-1 therapies
Pederson RA, Satkunaraja M, McIntosh CH, Scrocchi LA, Flamenz D, Schuit F, Drucker DJ, Wheeler MB

But the human trial protocols and clinical extrapolation from GLP-1-based therapies consistently show slower titration is the most effective intervention for reducing any and all gastrointestinal adverse events
