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R., Kempson, R

This is where appetite suppression becomes noticeable for most people

Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells

GLP-1s work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity in ways that compound over months of consistent use

The GLP-1 component reduces appetite through direct action on brain satiety centers while slowing gastric emptying
The safety profile, characterized by a higher incidence of gastrointestinal adverse events such as nausea, vomiting and diarrhea, is consistent with the drug's class but warrants especially careful consideration in a CKD population
