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In comparison to Ex-4, PEx-4 was more efficient in improving BACCO-induced cognitive impairment and cortical edema in diabetic rats ( As a major source of inflammatory cytokines in lesions after AIS, astrocytes play an important role in recruiting peripheral immune cells, activating microglia, aggravating brain injury, and destroying the BBB

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In the case of bullous pemphigoid, an autoinflammatory blistering skin disease, DPP4s role may involve impacting immune cell function and the formation of autoantibodies against skin components