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We think this will be important for people who are obese who also have MASH, a form of fatty liver disease, says Mehmet Furkan Burak, MD , an endocrinologist at Harvard Medical School who has done research on weight-loss medications

A study of secondary messenger inhibitors during GLP-1 or insulin administration revealed that AKT/PI3K and mitogen-activated protein kinase (MAPK) signaling are necessary for GLP-1 to exert its glycogenic effects [105]

N Engl J Med 2021;384(12):11131124

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