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doi: 10.1001/jamainternmed.2023.7268

It was found that semaglutide, a long-acting GLP-1RA, could improve symptoms caused by sepsis, reduce body temperature, and decrease the bacterial load in multiple organs, along with the levels of inflammatory factors in plasma and lungs

Additionally, some patients experience mild dehydration or nutrient shifts during the initial adjustment period, which may contribute to low energy levels

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The liver contains GLP-1 receptors, and activation appears to directly reduce hepatic lipogenesis (fat production in the liver), increase fatty acid oxidation, and reduce inflammatory signaling in hepatocytes

During US GLP-1 shortages a few years ago, pharmacies were also permitted to produce compounded semaglutide and tirzepatide, but the FDA says that exemption ended once supplies recovered in early 2025