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Semaglutide, the active ingredient in well known injectables like Ozempic and Wegovy, works by mimicking GLP-1, a hormone that helps regulate blood sugar, curb cravings, and promote steady weight loss.

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In addition to 564 semaglutide analogues, the structural biophysical analysis here also reveal the presence of an electrostatic scaffold comprising four salt bridges at the semaglutide-GLP-1R binding interface