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Up to now, most explanations have centered on the brain, lower dopamine signaling, reduced craving, less reactivity to alcohol cues in reward regions like the ventral tegmental area and nucleus accumbens

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Certainly, the apparent advantage of tirzepatide, a dual incretin agonist, over GLP-1RA will spark renewed interest in the therapeutic potential of GIP in type 2 diabetes, obesity and related co-morbidities.

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