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Both triple and dual receptor agonists show similar enhancement of cAMP production in comparison to single GLP-1 receptor agonists [75]

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There is a smooth transition between nonspecific binding and cross reactivities

The risk is highest early in therapy, with significant implications for surgical safety

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ANCOVA accounting for changes in body weight shows that, similarly to what was observed in mice at RT, EE was higher in semaglutide-treated mice throughout the treatment period, and this was further increased on stopping treatment (Fig